ZYME · Zymeworks Inc.

NASDAQ NMS - GLOBAL MARKET - Real Time Price • USD

Zymeworks Inc (ZYME)

NASDAQ NMS - GLOBAL MARKET Biotechnology
Move probability → Options chain →
$28.13 +1.23 (+4.59%)
● At close: October 21 at 4:00:00 PM EDT
DAY'S RANGE $28.13
$26.92 $28.25
52-WEEK RANGE $28.13
$16.00 $31.34

What's happening

Deterministic template sentences filled in from the same sourced figures shown elsewhere on this page -- not an AI-written summary, no live model call.

Key Statistics

Market Cap$1.63B
P/E (TTM1)—
EPS2 (TTM)$-2.01
Div Yield—
Beta31.32
Volume49,482
Open26.92
Prev Close26.89
Bid / Ask22.85 / 32.60
Next Earnings 2026-11-09

Analyst Recommendations

Strong buy 7 Buy 11 Hold 1 Sell 0 Strong sell 0

Aggregate ratings for 2026-10-01 (19 analysts polled by Finnhub) — consensus count.

Performance Overview (Trailing returns vs S&P 500 benchmark)

YTD RETURN
ZYME +2.20%
vs S&P 500 -10.57%
1-YEAR RETURN
ZYME +46.89%
vs S&P 500 +32.33%
6-MONTH RETURN
ZYME -1.07%
3-MONTH RETURN
ZYME +11.89%

Valuation Measures & Ratios

Enterprise Value4$2.16B
Forward P/E522.84
PEG Ratio6—
Price / Sales (TTM1)56.18
Price / Book723.28
EV4 / Revenue58.15
EV4 / EBITDA10.19
Profit Margin-404.00%
Operating Margin-418.99%
Return on Equity (ROE8)-72.07%
Return on Assets (ROA9)-37.06%
Avg Volume (3M)775,950
Quarterly history (5 periods)
Measure Jun '26Mar '26Sep '25Jun '25Mar '25
Market cap $1.90B $1.87B $1.29B $970.1M $899.4M
P/E -17.81 -22.28 -18.46 -11.04 -7.38
Price/Sales 22.76 17.70 10.78 8.73 12.43
Price/Book 23.60 11.45 4.02 2.90 2.77
EV/Revenue 20.61 15.39 10.24 7.85 11.37
ROE -132.47% -51.40% -21.80% -26.26% -37.49%
ROA -26.82% -17.58% -17.56% -21.51% -28.63%

Trailing-twelve-month ratios computed from SEC EDGAR quarterly figures and historical daily close prices (Alpaca). Diluted shares are derived from Net income ÷ EPS (diluted) for each quarter, not separately reported. Forward P/E/PEG unavailable (no free data source).

Glossary — what these abbreviations mean
1. TTM
Trailing twelve months — the sum of the last four reported quarters, not a calendar year or the single latest quarter.
2. EPS
Earnings per share — net income divided by diluted shares outstanding.
3. Beta
A stock's historical volatility relative to the overall market. Above 1 means it has moved more than the market; below 1, less.
4. EV (Enterprise Value)
Market cap plus total debt minus cash — roughly what it would cost to buy the whole company, debt included.
5. Forward P/E
Price divided by analysts' estimated earnings for the next 12 months, instead of trailing actual earnings.
6. PEG Ratio
P/E divided by expected earnings growth rate. A lower number can indicate a stock is cheap relative to how fast it's expected to grow.
7. Price / Book
Share price divided by book value (assets minus liabilities) per share.
8. ROE
Return on equity — net income divided by shareholders' equity, a measure of how efficiently a company turns equity into profit.
9. ROA
Return on assets — net income divided by total assets, a measure of how efficiently a company turns assets into profit.
10. MRQ
Most recent quarter — the single latest reported period, as opposed to TTM. The Financials section's "Quarterly" view below shows MRQ-style figures.
11. YoY
Year over year — percent change versus the same period one year earlier, used for growth figures like those on Compare cards and the Screener.

Short Interest

Shares Short5,291,136
Change from Prior Settlement+7.13%
% of Float—
Days to Cover (Short Ratio)5.55

Source: FINRA Rule 4560 consolidated short interest, settlement date 2026-09-30. Reported bi-monthly with a reporting lag — not real-time.

Quotes and the 1-day extended-hours chart: Yahoo Finance. Longer historical charts: Alpaca (IEX feed) — real-time but IEX-only volume (~2.5% of consolidated market volume). Fundamentals + earnings: Finnhub.

Price history

Events

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Technical signal summary

Calculating from the latest year of daily price history…

Calculating…
Show Technical Analysis Breakdown ▾ 10 Indicators

Not investment advice — read several signals together.

Indicators None active

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Starter sets
Trend
Oscillators
Volume/volatility
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History limited by data provider; markers are heuristics, not signals.

Peer and sector context

No reviewed peer group is available for this symbol.

Balanced evidence

A deterministic summary of sourced facts—not an AI verdict.

Potential strengths

Potential concerns

Rule-based facts only; absence from either side is not evidence, and this is not a recommendation.

Financials

Income statement

Line item Jun '26Mar '26Sep '25Jun '25Mar '25Sep '24Jun '24Mar '24
Revenue $4.6M $2.4M $27.6M $48.7M $27.1M $16.0M $19.2M $10.0M
Operating income -$42.2M -$47.1M -$22.1M -$674.0K -$25.6M -$34.2M -$42.9M -$37.8M
Net income -$45.0M -$44.2M -$19.6M $2.3M -$22.6M -$29.9M -$37.7M -$31.7M
EPS (diluted) $-0.62 $-0.59 $-0.26 $0.03 $-0.30 $-0.39 $-0.49 $-0.42
EPS (basic) $-0.62 $-0.59 $-0.26 $0.03 $-0.30 $-0.39 $-0.49 $-0.42
Operating margin -$919 -$2.0K -$80 -$1 -$94 -$214 -$223 -$377

Balance sheet

Line item Jun '26Mar '26Dec '25Sep '25Jun '25Mar '25Dec '24Sep '24
Total assets $397.0M $478.2M $346.5M $397.3M $408.4M $425.5M $463.1M $487.2M
Total liabilities $316.6M $314.6M $78.0M $77.2M $73.9M $100.6M $124.3M $120.2M
Stockholders' equity $80.4M $163.6M $268.5M $320.1M $334.5M $325.0M $338.8M $367.0M
Total current assets $298.4M $385.7M $248.8M $291.7M $296.1M $306.5M $300.5M $343.8M
Total current liabilities $47.2M $35.6M $42.3M $42.0M $38.5M $65.1M $88.3M $83.9M
Cash & equivalents $179.4M $244.3M $41.2M $64.8M $98.3M $76.2M $66.1M $122.4M

Cash flow

Line item Jun '26Mar '26Dec '25Sep '25Jun '25Mar '25Dec '24Sep '24
Operating cash flow -$31.9M -$45.7M -$10.3M -$31.4M $12.1M -$3.4M -$41.5M -$5.9M
Investing cash flow $17.1M $70.0M $5.4M $368.0K $8.7M $12.2M -$6.2M $72.3M
Financing cash flow -$50.0M $178.8M -$18.7M -$2.5M $1.3M $1.3M -$8.6M -$15.0M
Free cash flow -$31.9M -$45.9M -$10.8M -$31.8M $11.6M -$3.4M -$41.8M -$6.8M
Capital expenditures $0 $216.0K $581.0K $410.0K $514.0K $16.0K $314.0K $899.0K
Share-based compensation $11.3M $6.9M $8.8M $6.9M $5.9M $6.4M $5.0M $4.7M

Source: SEC EDGAR XBRL filings (10-Q/10-K), as originally tagged by the company. Quarterly cash flow is reconstructed by de-cumulating fiscal-year-to-date figures (how cash flow is tagged in 10-Qs); other quarterly lines are reported directly.

Institutional holders

SEC Form 13F filers holding ZYME as of the latest reported quarter. 13F only covers investment managers with $100M+ in assets — this is not a complete ownership picture, and does not include insiders (see Recent SEC filings below) or non-13F-eligible holders.

Source: Business Quant SEC Form 13F · report period 2026-06-30 · 30 filers

Held by These Filers84.0%
Shares Outstanding72,993,313
FilerSharesValue% OutQtr ChangeFiled
EcoR1 Capital, LLC 22,970,388 $600.4M 31.47% +0.0% 2026-08-14
Rubric Capital Management LP 7,000,000 $183.0M 9.59% +0.0% 2026-08-14
BlackRock, Inc. 4,251,030 $111.1M 5.82% -6.7% 2026-08-07
PERCEPTIVE ADVISORS LLC 4,182,953 $109.3M 5.73% +19.2% 2026-08-14
BVF INC/IL 3,649,142 $95.4M 5.00% -2.3% 2026-08-14
Morgan Stanley 2,231,260 $58.3M 3.06% -10.1% 2026-08-11
BNP Paribas Asset Management Holding S.A. 1,781,116 $46.6M 2.44% -6.7% 2026-08-12
VANGUARD CAPITAL MANAGEMENT LLC 1,558,998 $40.8M 2.14% -8.6% 2026-06-30
Assenagon Asset Management S.A. 1,252,027 $32.7M 1.72% +72.0% 2026-07-08
Nextech Invest Ltd. 1,113,946 $29.1M 1.53% +0.0% 2026-08-14
State Street Corp 1,088,216 $28.4M 1.49% +7.6% 2026-08-07
DIMENSIONAL FUND ADVISORS LP 994,955 $26.0M 1.36% -12.7% 2026-08-11
CITADEL ADVISORS LLC 914,136 $23.9M 1.25% -20.5% 2026-08-14
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 889,802 $23.3M 1.22% +0.0% 2026-08-14
FMR LLC 702,568 $18.4M 0.96% +5.3% 2026-08-13
GEODE CAPITAL MANAGEMENT, LLC 692,410 $18.1M 0.95% +4.9% 2026-08-12
Prosight Management, LP 674,434 $17.6M 0.92% +0.0% 2026-08-14
Qube Research & Technologies Ltd 593,590 $15.5M 0.81% +15.9% 2026-08-14
VANGUARD PORTFOLIO MANAGEMENT LLC 510,032 $13.3M 0.70% +2.0% 2026-06-30
Redmile Group, LLC 491,654 $12.9M 0.67% +0.0% 2026-08-14
Capricorn Fund Managers Ltd 486,529 $12.7M 0.67% -51.7% 2026-07-24
Goldman Sachs Group Inc 470,822 $12.3M 0.65% -21.5% 2026-08-14
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 418,497 $10.9M 0.57% -43.7% 2026-08-13
DEUTSCHE BANK AG\ 397,190 $10.4M 0.54% -56.9% 2026-08-07
Hillsdale Investment Management Inc. 382,922 $10.0M 0.52% +10.8% 2026-08-11

Insider activity

Directors, officers, and 10%+ owners' reported transactions from SEC Form 4. A filing reports a transaction; it does not by itself explain why it happened.

Source: SEC EDGAR Form 4 filings · checked 25 most recent filings · covers 2025-06-26 to 2026-10-09

Recent transactions

  • Insiders have net sold 13,832 shares over the last 182 days, across 0 purchases and 1 sale.
  • Most recent: Schayowitz Adam (EVP, Head of R&D) — Option exercise of 37,037 shares on 2026-10-09.

Deterministic template sentences filled in from the SEC Form 4 figures in the tables below -- not an AI-written summary, no live model call.

Insider purchases & sales, last 6 months

Purchases (open market)0 sh(0 txns)
Sales (open market)13,832 sh(1 txns)
Net Shares-13,832

Counts only open-market purchases (code P) and sales (code S) — grants, option exercises, tax withholding, and gifts are excluded since they aren't a market buy/sell decision.

Insider roster

NameTitleMost Recent TransactionDateShares
Schayowitz AdamEVP, Head of R&DOption exercise2026-10-0937,037
Hollywood MarkEVP & Chief Operating OfficerGrant / award2026-07-06939
Smith Jeffrey T LEVP & Chief Medical OfficerOption exercise2026-01-1217,666
Moore Paul AndrewChief Scientific OfficerOption exercise2026-01-1217,666
Galbraith KennethChair & CEOOption exercise2026-01-1264,000
PATTERSON LEONE DEVP, Chief Bus & Fin OfficerGrant / award2026-01-06459
Ciongoli Gregory AustinReporting personGrant / award2025-08-12415,000
EcoR1 Capital, LLCDirectorIn-the-money option exercise2025-06-265,086,480

Recent transactions

DateInsiderTitleTransactionSharesPrice
2026-10-09Schayowitz AdamEVP, Head of R&DOption exercise 37,037$0.00
2026-10-09Schayowitz AdamEVP, Head of R&DOpen market sale 13,832$25.85
2026-07-06Hollywood MarkEVP & Chief Operating OfficerGrant / award 939$22.22
2026-01-12Hollywood MarkEVP & Chief Operating OfficerOption exercise 17,666$0.00
2026-01-12Hollywood MarkEVP & Chief Operating OfficerOpen market sale 6,120$22.67
2026-01-12Smith Jeffrey T LEVP & Chief Medical OfficerOption exercise 17,666$0.00
2026-01-12Smith Jeffrey T LEVP & Chief Medical OfficerOpen market sale 9,310$22.67
2026-01-12Moore Paul AndrewChief Scientific OfficerOption exercise 17,666$0.00
2026-01-12Moore Paul AndrewChief Scientific OfficerOpen market sale 9,560$22.67
2026-01-12Galbraith KennethChair & CEOOption exercise 64,000$0.00
2026-01-12Galbraith KennethChair & CEOOpen market sale 30,424$22.67
2026-01-06PATTERSON LEONE DEVP, Chief Bus & Fin OfficerGrant / award 459$10.55
2026-01-05Smith Jeffrey T LEVP & Chief Medical OfficerOption exercise 20,000$0.00
2026-01-05Smith Jeffrey T LEVP & Chief Medical OfficerOpen market sale 10,538$25.10
2026-01-05Galbraith KennethChair & CEOOption exercise 47,668$0.00
2026-01-05Galbraith KennethChair & CEOOpen market sale 22,657$25.10
2026-01-05Galbraith KennethChair & CEOOption exercise 66,666$0.00
2026-01-05Galbraith KennethChair & CEOOpen market sale 31,686$25.10
2026-01-05Moore Paul AndrewChief Scientific OfficerOption exercise 17,168$0.00
2026-01-05Moore Paul AndrewChief Scientific OfficerOpen market sale 9,289$25.10
2026-01-05Moore Paul AndrewChief Scientific OfficerOption exercise 20,000$0.00
2026-01-05Moore Paul AndrewChief Scientific OfficerOpen market sale 10,821$25.10
2025-12-22Galbraith KennethChair & CEOOption exercise 100,000$0.00
2025-12-22Galbraith KennethChair & CEOOpen market sale 47,528$27.02
2025-08-12Ciongoli Gregory AustinReporting personGrant / award 415,000$12.02
2025-06-26EcoR1 Capital, LLCDirectorIn-the-money option exercise 5,086,480$0.00
2025-06-26EcoR1 Capital, LLCDirectorTax withholding 41$12.71

Recent SEC filings

Official company reports and insider transaction filings. Form 4 reports a transaction; it does not by itself explain why it happened.

Source: SEC EDGAR submissions · updated 2026-10-22 08:39 UTC

FiledFormReport periodOfficial filing
2026-10-0942026-10-09 View on SEC.gov →
2026-09-238-K2026-09-23 View on SEC.gov →
2026-08-258-K2026-08-25 View on SEC.gov →
2026-08-0610-Q2026-06-30 View on SEC.gov →
2026-08-068-K2026-08-06 View on SEC.gov →
2026-07-0642026-07-06 View on SEC.gov →
2026-06-298-K2026-06-28 View on SEC.gov →
2026-05-1542026-05-13 View on SEC.gov →
2026-05-148-K2026-05-14 View on SEC.gov →
2026-05-0710-Q2026-03-31 View on SEC.gov →
2026-05-078-K2026-05-07 View on SEC.gov →
2026-04-1042026-04-09 View on SEC.gov →

Headlines about ZYME (Zymeworks Inc.). Links open the publisher — we don’t host full articles.

SEC filings ↓

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