SYBX · SYNLOGIC INC
What's happening
- SYBX is down 49.46% today, trading at $0.58. — Live quote
- It's trading within 3% of its 52-week low ($0.54). (Finnhub fundamentals)
- Reports earnings on 2026-11-11, 20 days away. (Finnhub earnings calendar)
- Last quarter's EPS beat estimates: $-0.06 actual vs. $-0.10 estimated (+41.2%). (Finnhub earnings history)
Deterministic template sentences filled in from the same sourced figures shown elsewhere on this page -- not an AI-written summary, no live model call.
Key Statistics
Analyst Recommendations
Aggregate ratings for 2025-05-01 (6 analysts polled by Finnhub) — consensus count.
Performance Overview (Trailing returns vs S&P 500 benchmark)
Earnings Trends (Quarterly EPS Actual vs Estimate)
Valuation Measures & Ratios
Quarterly history (5 periods)
| Measure | Jun '26 | Mar '26 | Sep '25 | Jun '25 | Mar '25 |
|---|---|---|---|---|---|
| Market cap | $7.8M | $7.8M | $2.5M | $2.0M | $1.7M |
| P/E | -2.91 | -4.28 | -0.96 | 0.74 | -0.08 |
| Price/Sales | — | — | — | — | 217.94 |
| Price/Book | 0.65 | 0.63 | 0.24 | 0.16 | 0.13 |
| EV/Revenue | — | — | — | — | -1940.94 |
| ROE | -22.40% | -14.59% | -25.47% | 21.83% | -170.53% |
| ROA | -19.97% | -12.54% | -15.89% | 15.83% | -124.28% |
Trailing-twelve-month ratios computed from SEC EDGAR quarterly figures and historical daily close prices (Alpaca). Diluted shares are derived from Net income ÷ EPS (diluted) for each quarter, not separately reported. Forward P/E/PEG unavailable (no free data source).
Glossary — what these abbreviations mean
- 1. TTM
- Trailing twelve months — the sum of the last four reported quarters, not a calendar year or the single latest quarter.
- 2. EPS
- Earnings per share — net income divided by diluted shares outstanding.
- 3. Beta
- A stock's historical volatility relative to the overall market. Above 1 means it has moved more than the market; below 1, less.
- 4. EV (Enterprise Value)
- Market cap plus total debt minus cash — roughly what it would cost to buy the whole company, debt included.
- 5. Forward P/E
- Price divided by analysts' estimated earnings for the next 12 months, instead of trailing actual earnings.
- 6. PEG Ratio
- P/E divided by expected earnings growth rate. A lower number can indicate a stock is cheap relative to how fast it's expected to grow.
- 7. Price / Book
- Share price divided by book value (assets minus liabilities) per share.
- 8. ROE
- Return on equity — net income divided by shareholders' equity, a measure of how efficiently a company turns equity into profit.
- 9. ROA
- Return on assets — net income divided by total assets, a measure of how efficiently a company turns assets into profit.
- 10. MRQ
- Most recent quarter — the single latest reported period, as opposed to TTM. The Financials section's "Quarterly" view below shows MRQ-style figures.
- 11. YoY
- Year over year — percent change versus the same period one year earlier, used for growth figures like those on Compare cards and the Screener.
Short Interest
Source: FINRA Rule 4560 consolidated short interest, settlement date 2026-09-30. Reported bi-monthly with a reporting lag — not real-time.
Quotes and the 1-day extended-hours chart: Yahoo Finance. Longer historical charts: Alpaca (IEX feed) — real-time but IEX-only volume (~2.5% of consolidated market volume). Fundamentals + earnings: Finnhub.
Price history
Drag horizontally to zoom into a section; use Reset view to restore all observations.
Technical signal summary
Calculating from the latest year of daily price history…
Show Technical Analysis Breakdown ▾ 10 Indicators
Not investment advice — read several signals together.
Indicators None active
History limited by data provider; markers are heuristics, not signals.
Peer and sector context
Balanced evidence
A deterministic summary of sourced facts—not an AI verdict.
Potential strengths
- Latest SEC filing is Form 4, filed 2026-08-14; review it for current changes and risks. SEC EDGAR ↗
Potential concerns
- Net profit margin is -2283.4%. Finnhub fundamentals ↗
- Trailing 52-week price return is -78.6%. Finnhub market metrics ↗
Rule-based facts only; absence from either side is not evidence, and this is not a recommendation.
More on SYBX
No accessible free API for these — links go to the source directly.
Financials
Fundamental trends
Visualized from the same SEC figures in the tables below.
Income statement
| Line item | Jun '26 | Mar '26 | Sep '25 | Jun '25 | Mar '25 | Sep '24 | Jun '24 | Mar '24 |
|---|---|---|---|---|---|---|---|---|
| Revenue | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $8.0K |
| Operating income | -$1.0M | -$1.3M | -$991.0K | -$777.0K | -$898.0K | -$748.0K | $419.0K | -$38.8M |
| Net income | -$543.0K | $681.0K | -$2.3M | -$529.0K | $317.0K | -$117.0K | $3.1M | -$25.6M |
| EPS (diluted) | $-0.04 | $0.05 | $-0.19 | $-0.04 | $0.03 | $-0.01 | $0.25 | $-2.11 |
| EPS (basic) | $-0.04 | $0.05 | $-0.19 | $-0.04 | $0.03 | $-0.01 | $0.25 | $-2.11 |
| Operating margin | — | — | — | — | — | — | — | -$485.6K |
| Net margin | — | — | — | — | — | — | — | -$320.1K |
Balance sheet
| Line item | Jun '26 | Mar '26 | Dec '25 | Sep '25 | Jun '25 | Mar '25 | Dec '24 | Sep '24 |
|---|---|---|---|---|---|---|---|---|
| Total assets | $13.5M | $14.6M | $15.4M | $16.6M | $17.4M | $18.0M | $19.8M | $20.8M |
| Total liabilities | — | — | — | — | — | — | — | — |
| Stockholders' equity | $12.0M | $12.6M | $11.9M | $10.3M | $12.6M | $13.1M | $12.8M | $13.1M |
| Total current assets | $13.4M | $14.6M | $15.4M | $16.5M | $17.3M | $17.9M | $19.8M | $20.7M |
| Total current liabilities | $1.5M | $2.1M | $3.6M | $6.2M | $4.8M | $4.9M | $7.1M | $7.6M |
| Cash & equivalents | $13.2M | $14.1M | $14.7M | $15.6M | $17.0M | $17.3M | $18.9M | $19.4M |
| Accounts receivable | — | — | — | — | — | — | — | — |
| Other current assets | $42.0K | $43.0K | $48.0K | $55.0K | $59.0K | $63.0K | $75.0K | $156.0K |
| Marketable securities (non-current) | — | — | — | — | — | — | — | — |
| Property, plant & equipment | — | — | — | — | — | — | $0 | $0 |
| Other non-current assets | — | — | — | — | — | — | $0 | $0 |
| Accounts payable | $80.0K | $206.0K | $103.0K | $107.0K | $45.0K | $80.0K | $164.0K | $178.0K |
| Accrued liabilities | $1.0M | $1.2M | $915.0K | $858.0K | $952.0K | $946.0K | $2.0M | $1.8M |
| Deferred revenue (current) | — | — | — | — | — | — | — | — |
| Other non-current liabilities | — | — | — | — | — | — | — | — |
| Common stock & paid-in capital | $12.0K | $12.0K | $12.0K | $12.0K | $12.0K | $12.0K | $12.0K | $12.0K |
| Retained earnings | -$442.5M | -$442.0M | -$442.7M | -$444.2M | -$441.9M | -$441.3M | -$441.7M | -$440.9M |
| Accumulated other comprehensive income (loss) | — | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
Cash flow
| Line item | Jun '26 | Mar '26 | Dec '25 | Sep '25 | Jun '25 | Mar '25 | Dec '24 | Sep '24 |
|---|---|---|---|---|---|---|---|---|
| Operating cash flow | -$922.0K | -$563.0K | -$923.0K | -$1.4M | -$399.0K | -$1.6M | -$568.0K | -$648.0K |
| Investing cash flow | $0 | $0 | $0 | $0 | $155.0K | $12.0K | $30.0K | $72.0K |
| Financing cash flow | — | — | $0 | $0 | $0 | $0 | $9.0K | -$1.0K |
| Free cash flow | — | — | -$923.0K | -$1.4M | -$399.0K | -$1.6M | -$568.0K | -$648.0K |
| Capital expenditures | — | — | $0 | $0 | $0 | $0 | $0 | $0 |
| Depreciation & amortization | — | — | — | — | — | — | — | — |
| Share-based compensation | $6.0K | $10.0K | $92.0K | $33.0K | $29.0K | $25.0K | $948.0K | $102.0K |
| Change in accounts receivable | — | — | — | — | — | — | — | — |
| Change in accounts payable | — | — | — | — | — | — | — | — |
| Purchases of investments | — | — | $0 | $0 | $0 | $0 | $0 | $0 |
| Sales/maturities of investments | — | — | — | — | — | — | — | — |
| Tax withholding on stock comp | — | — | — | — | — | — | — | — |
Income statement
| Line item | Dec '25 | Dec '24 | Dec '23 | Dec '22 | Dec '21 |
|---|---|---|---|---|---|
| Revenue | $0 | $8.0K | $3.4M | $1.2M | $1.8M |
| Operating income | -$4.0M | -$41.0M | -$55.2M | -$67.4M | -$60.8M |
| Net income | -$1.0M | -$23.4M | -$61.3M | -$66.1M | -$60.6M |
| EPS (diluted) | $-0.08 | $-1.92 | $-9.42 | $-13.83 | $-1.09 |
| EPS (basic) | $-0.08 | $-1.92 | $-9.42 | $-13.83 | $-1.09 |
| Operating margin | — | -$511.9K | -$1.6K | -$5.7K | -$3.5K |
| Net margin | — | -$292.0K | -$1.8K | -$5.6K | -$3.5K |
Balance sheet
| Line item | Dec '25 | Dec '24 | Dec '23 | Dec '22 | Dec '21 |
|---|---|---|---|---|---|
| Total assets | $15.4M | $19.8M | $75.5M | $110.9M | $174.7M |
| Total liabilities | — | — | — | — | — |
| Stockholders' equity | $11.9M | $12.8M | $32.8M | $82.6M | $147.3M |
| Total current assets | $15.4M | $19.8M | $49.9M | $79.8M | $133.3M |
| Total current liabilities | $3.6M | $7.1M | $30.3M | $12.1M | $10.1M |
| Cash & equivalents | $14.7M | $18.9M | $24.0M | $15.9M | $16.4M |
| Other current assets | $48.0K | $75.0K | $146.0K | $175.0K | $311.0K |
| Marketable securities (non-current) | — | — | — | — | — |
| Property, plant & equipment | — | $0 | $5.6M | $7.3M | $9.1M |
| Other non-current assets | — | $0 | $16.0K | $7.0K | $3.0K |
| Accounts payable | $103.0K | $164.0K | $1.5M | $1.8M | $1.9M |
| Accrued liabilities | $915.0K | $2.0M | $3.0M | $5.3M | $4.4M |
| Deferred revenue (current) | — | — | $0 | $882.0K | $531.0K |
| Other non-current liabilities | — | — | — | — | — |
| Common stock & paid-in capital | $12.0K | $12.0K | $10.0K | $5.0K | $70.0K |
| Retained earnings | -$442.7M | -$441.7M | -$418.3M | -$357.0M | -$290.9M |
| Accumulated other comprehensive income (loss) | $0 | $0 | $6.0K | -$161.0K | -$45.0K |
Cash flow
| Line item | Dec '25 | Dec '24 | Dec '23 | Dec '22 | Dec '21 |
|---|---|---|---|---|---|
| Operating cash flow | -$4.4M | -$31.7M | -$51.6M | -$56.9M | -$52.2M |
| Investing cash flow | $167.0K | $25.3M | $38.8M | $58.4M | -$53.3M |
| Financing cash flow | $0 | $172.0K | $20.9M | -$2.0M | $89.4M |
| Free cash flow | -$4.4M | -$31.7M | -$51.8M | -$57.6M | -$52.9M |
| Capital expenditures | $0 | $14.0K | $214.0K | $728.0K | $679.0K |
| Depreciation & amortization | — | — | — | — | — |
| Share-based compensation | $117.0K | $3.2M | $2.8M | $3.6M | $3.4M |
| Change in accounts payable | — | — | — | — | — |
| Purchases of investments | $0 | $1.5M | $27.9M | $82.8M | $167.9M |
| Sales/maturities of investments | — | — | — | $0 | $1.3M |
| Tax withholding on stock comp | — | — | — | $0 | $73.0K |
Source: SEC EDGAR XBRL filings (10-Q/10-K), as originally tagged by the company. Quarterly cash flow is reconstructed by de-cumulating fiscal-year-to-date figures (how cash flow is tagged in 10-Qs); other quarterly lines are reported directly.
Institutional holders
SEC Form 13F filers holding SYBX as of the latest reported quarter. 13F only covers investment managers with $100M+ in assets — this is not a complete ownership picture, and does not include insiders (see Recent SEC filings below) or non-13F-eligible holders.
Insider activity
Directors, officers, and 10%+ owners' reported transactions from SEC Form 4. A filing reports a transaction; it does not by itself explain why it happened.
Source: SEC EDGAR Form 4 filings · checked 25 most recent filings · covers 2023-04-03 to 2025-10-29
Recent transactions
- Most recent: Dooley Mary Beth (See Remarks below) — Open market sale of 157 shares on 2025-10-29.
Deterministic template sentences filled in from the SEC Form 4 figures in the tables below -- not an AI-written summary, no live model call.
Insider purchases & sales, last 6 months
Counts only open-market purchases (code P) and sales (code S) — grants, option exercises, tax withholding, and gifts are excluded since they aren't a market buy/sell decision.
Insider roster
| Name | Title | Most Recent Transaction | Date | Shares |
|---|---|---|---|---|
| Dooley Mary Beth | See Remarks below | Open market sale | 2025-10-29 | 157 |
| Shea Richard P | Reporting person | Grant / award | 2025-04-26 | 15,000 |
| Flynn James P | Reporting person | Grant / award | 2025-04-26 | 15,000 |
| Awad Antoine | Chief Operating Officer | Open market sale | 2024-04-02 | 372 |
| Brennan Aoife | See Remarks | Open market sale | 2023-04-03 | 19,042 |
Recent transactions
| Date | Insider | Title | Transaction | Shares | Price |
|---|---|---|---|---|---|
| 2025-10-29 | Dooley Mary Beth | See Remarks below | Open market sale | 157 | $1.81 |
| 2025-04-26 | Shea Richard P | Reporting person | Grant / award | 15,000 | $0.00 |
| 2025-04-26 | Flynn James P | Reporting person | Grant / award | 15,000 | $0.00 |
| 2025-04-02 | Dooley Mary Beth | See Remarks below | Open market sale | 144 | $1.20 |
| 2025-02-03 | Dooley Mary Beth | See Remarks below | Open market sale | 2,107 | $1.33 |
| 2024-10-29 | Dooley Mary Beth | Head of Finance | Open market sale | 79 | $1.40 |
Recent SEC filings
Official company reports and insider transaction filings. Form 4 reports a transaction; it does not by itself explain why it happened.
Source: SEC EDGAR submissions · updated 2026-10-21 23:37 UTC
| Filed | Form | Report period | Official filing |
|---|---|---|---|
| 2026-08-14 | 4 | 2026-07-27 | View on SEC.gov → |
| 2026-08-11 | 10-Q | 2026-06-30 | View on SEC.gov → |
| 2026-07-29 | 8-K | 2026-07-27 | View on SEC.gov → |
| 2026-05-14 | 10-Q | 2026-03-31 | View on SEC.gov → |
| 2026-03-12 | 10-K | 2025-12-31 | View on SEC.gov → |
| 2026-01-20 | 8-K | 2026-01-16 | View on SEC.gov → |
| 2025-12-16 | 8-K | 2025-12-15 | View on SEC.gov → |
| 2025-11-26 | 8-K | 2025-11-21 | View on SEC.gov → |
| 2025-11-13 | 10-Q | 2025-09-30 | View on SEC.gov → |
| 2025-10-31 | 4 | 2025-10-29 | View on SEC.gov → |
| 2025-08-07 | 10-Q | 2025-06-30 | View on SEC.gov → |
| 2025-05-08 | 10-Q | 2025-03-31 | View on SEC.gov → |
Recent news
Headlines about SYBX (SYNLOGIC INC). Links open the publisher — we don’t host full articles.
-
Synlogic and Caldera sign merger agreement
Yahoo Finance · 2026-07-30 -
Synlogic and Caldera Therapeutics Announce Merger and $278 Million Private Placement
Yahoo Finance · 2026-07-29 -
Caldera, Vidya add to recent flurry of biotech mergers
Yahoo Finance · 2026-07-29 -
Synlogic and Caldera Therapeutics Announce Merger Agreement and Concurrent Private Placement
Yahoo Finance · 2026-07-29 -
Synlogic files $150M mixed securities shelf
Seeking Alpha · 2025-08-08
No headlines in this category right now — try “All”.