SEPN · Septerna, Inc.

NASDAQ NMS - GLOBAL MARKET - BOATS Real Time Price • USD

Septerna Inc (SEPN)

NASDAQ NMS - GLOBAL MARKET Pharmaceuticals
Move probability → Options chain →
$40.73 +1.38 (+3.51%)
● At close: October 21 at 4:00:00 PM EDT
DAY'S RANGE $40.73
$39.53 $41.34
52-WEEK RANGE $40.73
$17.55 $51.10

What's happening

Deterministic template sentences filled in from the same sourced figures shown elsewhere on this page -- not an AI-written summary, no live model call.

Key Statistics

Market Cap$1.87B
P/E (TTM1)—
EPS2 (TTM)$-0.54
Div Yield—
Beta31.01
Volume13,669
Open39.53
Prev Close39.35
Bid / Ask35.00 / 0.00
Next Earnings 2026-11-09

Analyst Recommendations

Strong buy 5 Buy 10 Hold 1 Sell 0 Strong sell 0

Aggregate ratings for 2026-10-01 (16 analysts polled by Finnhub) — consensus count.

Performance Overview (Trailing returns vs S&P 500 benchmark)

YTD RETURN
SEPN +41.14%
vs S&P 500 +28.36%
1-YEAR RETURN
SEPN +75.36%
vs S&P 500 +60.80%
6-MONTH RETURN
SEPN +57.46%
3-MONTH RETURN
SEPN +16.83%

Valuation Measures & Ratios

Enterprise Value4$1.75B
Forward P/E5—
PEG Ratio6—
Price / Sales (TTM1)18.57
Price / Book73.90
EV4 / Revenue17.72
EV4 / EBITDA—
Profit Margin-24.51%
Operating Margin-44.04%
Return on Equity (ROE8)-6.31%
Return on Assets (ROA9)-4.14%
Avg Volume (3M)430,110
Quarterly history (5 periods)
Measure Jun '26Mar '26Sep '25Jun '25Mar '25
Market cap $1.51B $1.09B $854.5M $468.8M $253.3M
P/E -39.33 -23.32 -14.57 -5.62 -3.49
Price/Sales 20.13 22.56 38.83 530.34 234.13
Price/Book 3.90 2.88 2.20 1.24 0.63
EV/Revenue 19.00 21.08 24.29 316.18 40.00
EV/EBITDA -25.92 -15.93 -7.30 — —
ROE -9.91% -12.36% -15.09% -22.08% -18.14%
ROA -6.76% -8.21% -9.67% -20.07% -16.73%

Trailing-twelve-month ratios computed from SEC EDGAR quarterly figures and historical daily close prices (Alpaca). Diluted shares are derived from Net income ÷ EPS (diluted) for each quarter, not separately reported. Forward P/E/PEG unavailable (no free data source).

Glossary — what these abbreviations mean
1. TTM
Trailing twelve months — the sum of the last four reported quarters, not a calendar year or the single latest quarter.
2. EPS
Earnings per share — net income divided by diluted shares outstanding.
3. Beta
A stock's historical volatility relative to the overall market. Above 1 means it has moved more than the market; below 1, less.
4. EV (Enterprise Value)
Market cap plus total debt minus cash — roughly what it would cost to buy the whole company, debt included.
5. Forward P/E
Price divided by analysts' estimated earnings for the next 12 months, instead of trailing actual earnings.
6. PEG Ratio
P/E divided by expected earnings growth rate. A lower number can indicate a stock is cheap relative to how fast it's expected to grow.
7. Price / Book
Share price divided by book value (assets minus liabilities) per share.
8. ROE
Return on equity — net income divided by shareholders' equity, a measure of how efficiently a company turns equity into profit.
9. ROA
Return on assets — net income divided by total assets, a measure of how efficiently a company turns assets into profit.
10. MRQ
Most recent quarter — the single latest reported period, as opposed to TTM. The Financials section's "Quarterly" view below shows MRQ-style figures.
11. YoY
Year over year — percent change versus the same period one year earlier, used for growth figures like those on Compare cards and the Screener.

Short Interest

Shares Short3,096,190
Change from Prior Settlement+6.99%
% of Float—
Days to Cover (Short Ratio)8.80

Source: FINRA Rule 4560 consolidated short interest, settlement date 2026-09-30. Reported bi-monthly with a reporting lag — not real-time.

Quotes and the 1-day extended-hours chart: Yahoo Finance. Longer historical charts: Alpaca (IEX feed) — real-time but IEX-only volume (~2.5% of consolidated market volume). Fundamentals + earnings: Finnhub.

Price history

Events

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Technical signal summary

Calculating from the latest year of daily price history…

Calculating…
Show Technical Analysis Breakdown ▾ 10 Indicators

Not investment advice — read several signals together.

Indicators None active

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Starter sets
Trend
Oscillators
Volume/volatility
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History limited by data provider; markers are heuristics, not signals.

Peer and sector context

No reviewed peer group is available for this symbol.

Balanced evidence

A deterministic summary of sourced facts—not an AI verdict.

Potential strengths

Potential concerns

Rule-based facts only; absence from either side is not evidence, and this is not a recommendation.

Financials

Income statement

Line item Jun '26Mar '26Sep '25Jun '25Mar '25Sep '24Jun '24Mar '24
Revenue $26.7M $26.5M $21.5M $119.0K $219.0K $176.0K $370.0K $317.0K
Operating income -$16.8M -$13.3M $2.6M -$29.0M -$25.9M -$22.6M -$18.1M -$15.5M
Net income -$13.0M -$8.6M $8.2M -$24.8M -$21.5M -$20.5M -$16.5M -$14.1M
EPS (diluted) $-0.29 $-0.19 $0.18 $-0.56 $-0.49 $-8.40 $-7.03 $-6.35
EPS (basic) $-0.29 $-0.19 $0.18 $-0.56 $-0.49 $-8.40 $-7.03 $-6.35
Operating margin -$63 -$50 $12 -$24.4K -$11.8K -$12.8K -$4.9K -$4.9K

Balance sheet

Line item Jun '26Mar '26Dec '25Sep '25Jun '25Mar '25Dec '24Sep '24
Total assets $566.7M $569.7M $596.2M $606.7M $415.2M $434.0M $456.6M $174.3M
Total liabilities $180.0M $191.2M $214.3M $217.9M $37.7M $33.8M $36.5M $37.5M
Stockholders' equity $386.7M $378.5M $381.9M $388.7M $377.6M $400.3M $420.0M -$87.4M
Total current assets $396.2M $368.1M $411.0M $491.7M $334.1M $342.5M $356.8M $133.4M
Total current liabilities $79.3M $78.2M $86.9M $75.3M $15.1M $10.6M $12.8M $13.2M
Cash & equivalents $84.7M $71.6M $120.7M $320.0M $189.3M $210.0M $238.2M $88.2M

Cash flow

Line item Jun '26Mar '26Dec '25Sep '25Jun '25Mar '25Dec '24Sep '24
Operating cash flow -$22.2M -$25.6M -$15.0M $168.8M -$20.3M -$23.3M -$21.0M -$16.8M
Investing cash flow $18.4M -$23.8M -$185.3M -$38.4M -$786.0K -$4.9M -$133.2M -$24.8M
Financing cash flow $16.8M $333.0K $1.0M $263.0K $339.0K $66.0K $304.2M -$1.3M
Free cash flow -$22.2M -$26.5M -$15.1M $168.8M -$20.3M -$23.7M -$21.6M -$17.4M
Capital expenditures $0 $832.0K $65.0K $13.0K $58.0K $382.0K $612.0K $578.0K
Depreciation & amortization $400.0K $400.0K $1.2M $400.0K $400.0K $400.0K $1.1M $400.0K

Source: SEC EDGAR XBRL filings (10-Q/10-K), as originally tagged by the company. Quarterly cash flow is reconstructed by de-cumulating fiscal-year-to-date figures (how cash flow is tagged in 10-Qs); other quarterly lines are reported directly.

Institutional holders

SEC Form 13F filers holding SEPN as of the latest reported quarter. 13F only covers investment managers with $100M+ in assets — this is not a complete ownership picture, and does not include insiders (see Recent SEC filings below) or non-13F-eligible holders.

Institutional ownership is not available for this symbol right now.

Insider activity

Directors, officers, and 10%+ owners' reported transactions from SEC Form 4. A filing reports a transaction; it does not by itself explain why it happened.

Source: SEC EDGAR Form 4 filings · checked 25 most recent filings · covers 2026-02-18 to 2026-10-15

Recent transactions

  • Insiders have net sold 1,724,361 shares over the last 182 days, across 0 purchases and 21 sales.
  • Most recent: Bhatt Elizabeth (President and COO) — Option exercise of 4,000 shares on 2026-10-15.

Deterministic template sentences filled in from the SEC Form 4 figures in the tables below -- not an AI-written summary, no live model call.

Insider purchases & sales, last 6 months

Purchases (open market)0 sh(0 txns)
Sales (open market)1,724,361 sh(21 txns)
Net Shares-1,724,361

Counts only open-market purchases (code P) and sales (code S) — grants, option exercises, tax withholding, and gifts are excluded since they aren't a market buy/sell decision.

Insider roster

NameTitleMost Recent TransactionDateShares
Bhatt ElizabethPresident and COOOption exercise2026-10-154,000
Long Daniel D.SVP, Drug DiscoveryOption exercise2026-09-013,333
Third Rock Ventures V, L.P.Reporting personOpen market sale2026-08-12147,059
RA CAPITAL MANAGEMENT, L.P.Reporting personOpen market sale2026-08-12746,500
Shaikhly SamiraChief People OfficerOption exercise2026-06-292,178

Recent transactions

DateInsiderTitleTransactionSharesPrice
2026-10-15Bhatt ElizabethPresident and COOOption exercise 4,000$6.81
2026-10-15Bhatt ElizabethPresident and COOOpen market sale 1,094$36.87
2026-10-15Bhatt ElizabethPresident and COOOpen market sale 2,906$37.61
2026-09-01Long Daniel D.SVP, Drug DiscoveryOption exercise 3,333$2.76
2026-09-01Long Daniel D.SVP, Drug DiscoveryOpen market sale 3,333$37.83
2026-08-12Third Rock Ventures V, L.P.Reporting personOpen market sale 147,059$50.27
2026-08-12Third Rock Ventures V, L.P.Reporting personOpen market sale 141$51.08
2026-08-12RA CAPITAL MANAGEMENT, L.P.Reporting personOpen market sale 746,500$42.50
2026-08-12RA CAPITAL MANAGEMENT, L.P.Reporting personOpen market sale 746,500$42.50
2026-08-11Bhatt ElizabethPresident and COOOption exercise 18,681$6.81
2026-08-11Bhatt ElizabethPresident and COOOption exercise 6,319$2.76
2026-08-11Bhatt ElizabethPresident and COOOpen market sale 25,000$44.00
2026-08-03Long Daniel D.SVP, Drug DiscoveryOption exercise 1,816$2.76
2026-08-03Long Daniel D.SVP, Drug DiscoveryOption exercise 1,518$2.76
2026-08-03Long Daniel D.SVP, Drug DiscoveryOpen market sale 1,000$33.98
2026-08-03Long Daniel D.SVP, Drug DiscoveryOpen market sale 2,334$34.68
2026-07-15Bhatt ElizabethPresident and COOOption exercise 4,000$6.81
2026-07-15Bhatt ElizabethPresident and COOOpen market sale 4,000$33.99
2026-07-01Long Daniel D.SVP, Drug DiscoveryOption exercise 3,333$2.76
2026-07-01Long Daniel D.SVP, Drug DiscoveryOpen market sale 2,100$34.10
2026-07-01Long Daniel D.SVP, Drug DiscoveryOpen market sale 1,233$34.81
2026-06-29Shaikhly SamiraChief People OfficerOption exercise 2,178$6.81
2026-06-29Shaikhly SamiraChief People OfficerOpen market sale 2,178$35.18
2026-06-22Long Daniel D.SVP, Drug DiscoveryOption exercise 10,529$2.76
2026-06-22Long Daniel D.SVP, Drug DiscoveryOption exercise 4,471$11.70
2026-06-22Long Daniel D.SVP, Drug DiscoveryOpen market sale 8,000$35.10
2026-06-22Long Daniel D.SVP, Drug DiscoveryOpen market sale 7,000$35.97
2026-06-12Shaikhly SamiraChief People OfficerOption exercise 6,250$11.70
2026-06-12Shaikhly SamiraChief People OfficerOpen market sale 6,250$35.08
2026-06-01Shaikhly SamiraChief People OfficerOption exercise 4,355$1.55
2026-06-01Shaikhly SamiraChief People OfficerOption exercise 943$2.76
2026-06-01Shaikhly SamiraChief People OfficerOption exercise 637$2.76
2026-06-01Shaikhly SamiraChief People OfficerOpen market sale 1,700$27.78
2026-06-01Shaikhly SamiraChief People OfficerOpen market sale 1,346$28.79
2026-06-01Shaikhly SamiraChief People OfficerOpen market sale 2,889$29.66
2026-05-26Shaikhly SamiraChief People OfficerOption exercise 11,798$6.81
2026-05-26Shaikhly SamiraChief People OfficerOpen market sale 11,798$30.06
2026-04-15Bhatt ElizabethPresident and COOOption exercise 4,000$6.81
2026-04-15Bhatt ElizabethPresident and COOOpen market sale 2,573$23.76
2026-04-15Bhatt ElizabethPresident and COOOpen market sale 1,101$25.24
2026-04-15Bhatt ElizabethPresident and COOOpen market sale 326$25.86
2026-03-02Shaikhly SamiraChief People OfficerOption exercise 53,714$1.55
2026-03-02Shaikhly SamiraChief People OfficerOption exercise 11,638$2.76
2026-03-02Shaikhly SamiraChief People OfficerOption exercise 5,101$2.76
2026-03-02Shaikhly SamiraChief People OfficerOpen market sale 4,090$27.51
2026-03-02Shaikhly SamiraChief People OfficerOpen market sale 66,363$28.14
2026-02-18Bhatt ElizabethPresident and COOOption exercise 4,000$6.81
2026-02-18Bhatt ElizabethPresident and COOOpen market sale 2,200$28.46
2026-02-18Bhatt ElizabethPresident and COOOpen market sale 1,800$29.58

Recent SEC filings

Official company reports and insider transaction filings. Form 4 reports a transaction; it does not by itself explain why it happened.

Source: SEC EDGAR submissions · updated 2026-10-22 06:35 UTC

FiledFormReport periodOfficial filing
2026-10-1942026-10-15 View on SEC.gov →
2026-09-1042026-09-08 View on SEC.gov →
2026-09-0342026-09-01 View on SEC.gov →
2026-08-258-K2026-08-22 View on SEC.gov →
2026-08-1442026-08-12 View on SEC.gov →
2026-08-1442026-08-12 View on SEC.gov →
2026-08-1342026-08-11 View on SEC.gov →
2026-08-1010-Q2026-06-30 View on SEC.gov →
2026-08-108-K2026-08-10 View on SEC.gov →
2026-08-0542026-08-03 View on SEC.gov →
2026-07-1742026-07-15 View on SEC.gov →
2026-07-0242026-07-01 View on SEC.gov →

Headlines about SEPN (Septerna, Inc.). Links open the publisher — we don’t host full articles.

SEC filings ↓

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